Evidence Library (studies & reviews)

A) Landmark clinical studies: facial rejuvenation (red / NIR LEDs)

  • Lee et al., 2007 — Double-blind split-face design; compared 830 nm, 633 nm, combo vs sham; reported clinical + profilometric + histologic/ultrastructural changes consistent with rejuvenation outcomes. ScienceDirect+1

  • Wunsch & colleagues, 2014 — Controlled trial in photobiomodulation context; reports improvements in wrinkles/skin roughness and collagen density endpoints (device-based PBM). PMC+1

  • Couturaud et al., 2023 — Clinical paper on red LED mask protocol (630 ± 10 nm) with reported improvements in facial aging signs. PMC

  • Russell, Kellett & Reilly, 2005 — Combination 633/830 nm LED in facial rejuvenation (often cited in later reviews). PMC+1

  • Mota et al., 2023 — Clinical paper focusing on periocular wrinkle volume reduction with PBM parameters (adds to wrinkle-specific evidence). Liebert Publishing

B) Acne: blue light, red light, and combined protocols

  • Diogo et al., 2021 (Systematic Review) — Synthesizes blue-light acne evidence, including randomized and split-face designs; highlights meaningful lesion reductions in several protocols and variability in methods. PMC

  • Hamilton et al., 2009 (Systematic Review of RCTs) — Classic dermatology systematic review of light/laser therapies for acne; discusses the quality and limitations of RCT evidence. OUP Academic

  • Akuffo-Addo et al., 2024 (Review) — Overview of visible light (especially blue) in acne contexts and remission/response patterns across reported studies. PMC

  • Uzunbajakava et al., 2023 (Review) — Discusses nuances/parameters and summarizes controlled acne trials (blue light high-intensity arrays among cited examples). Wiley Online Library

  • Ablon, 2025 (Open-label study summary) — Evaluates combined blue (415 nm) + red (633 nm) phototherapy approach for acne lesion improvement signals. JCAD

  • Jean-Pierre et al., 2024 (Review) — Mechanistic framing of blue light penetration and porphyrin absorption range relevant to acne protocols. Springer

C) Psoriasis & broader inflammatory dermatology (more mixed; often adjunctive)

  • Ablon et al., 2010 — Combination 830 nm + 633 nm LED phototherapy in recalcitrant psoriasis (clinical outcomes reported; preliminary but frequently cited). PubMed+1

  • Zhang et al., 2017 (Clinical review of phototherapy for psoriasis) — Summarizes phototherapy modalities and includes LED protocol outcomes in plaque psoriasis contexts. PMC

  • Kemény et al., 2019 (Review) — Discusses advances in phototherapy for psoriasis and atopic dermatitis, including low-level light/LED wavelengths in clinical context. Taylor & Francis Online

  • Cho et al., 2017 (Preclinical AD model) — LED phototherapy with longer wavelengths improving AD-like lesions in a mouse model (mechanistic support, not a human RCT). PMC

  • Blue light eczema trial (prospective randomized local treatment) — Blue LED exposure vs contralateral control lesion design (small sample; signals of benefit reported). ResearchGate+1

D) Rosacea / redness pathways (emerging)

  • Wu et al., 2022 — PBM and rosacea inflammatory mediator pathway analysis; suggests PBM may improve rosacea via inflammation/angiogenesis signaling modulation (research-oriented; not a consumer device claim by itself). PMC

E) Wound healing & tissue repair context 

  • Felician et al., 2023 (Review) — Broad PBM review across cellular/molecular and clinical aspects; includes wound/ulcer evidence and parameter discussions. ScienceDirect

  • Prado et al., 2023 (Scoping Review) — Blue light PBM and wound healing process literature mapping (heterogeneous, but informative). PMC

  • De Angelis et al., 2025 — Clinical wound-healing outcomes with PBM reported over longer follow-up (shows that timing/endpoints matter). MDPI

F) Safety & clinical guidance

  • Glass et al., 2023 (Systematic review on oncologic safety framing) — Summarizes clinical/preclinical evidence and safety considerations around PBM in aesthetic settings. PMC

  • Mineroff et al., 2024 (JAAD CME review) — Dermatology education review on PBM clinical applications; emphasizes parameter tailoring and the need for standardized recommendations. ScienceDirect+1

  • Maghfour et al., 2025 (Consensus / evidence-based guidance) — Evidence-based consensus approach to PBM clinical application (useful for “how to use responsibly” sections). JAAD

  • Werner et al., 2025 (Blue light review: benefits + risks) — Balanced discussion: therapeutic potential but also cautions (e.g., pigmentation/oxidative stress considerations), supporting “safe use” messaging. ScienceDirect